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Tuesday, May 5, 2020 | History

2 edition of Bioassay of chlorpropamide for possible carcinogenicity. found in the catalog.

Bioassay of chlorpropamide for possible carcinogenicity.

National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Bioassay of chlorpropamide for possible carcinogenicity.

by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

  • 315 Want to read
  • 40 Currently reading

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Hypoglycemic agents.,
  • Poisons.,
  • Toxicology.

  • Edition Notes

    SeriesDHEW publication ; no. (NIH) 78-845, Carcinogenesis technical report series ; no. 45, National Cancer Institute carcinogenesis technical report series -- no. 45., DHEW publication -- no. (NIH) 78-845.
    The Physical Object
    Paginationxi, 86 p. :
    Number of Pages86
    ID Numbers
    Open LibraryOL17535065M

    Because chlorpropamide has a long half-life, hypoglycemia can be severe, although onset is not as fast or as dramatic as with use of insulin. Report any of the following immediately to physician: skin eruptions, malaise, fever, or photosensitivity. Immediately report these symptoms to physician. identify relevant indicators of toxicity of nanomaterials including possible precursors of carcinogenicity. Due to the heterogeneous characteristics of the materials and the different study types, a structured and systematic data analysis was performed by means of a relational database (PaFtox). More than inhalation studies.

    Chlorpropamide causes the pancreas to produce insulin and increases your body's response to it. Chlorpropamide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Chlorpropamide is not for treating type 1 diabetes.. Chlorpropamide may also be used for purposes not listed in this medication guide. Bioassay method for toxicity studies Ciênc. agrotec., Lavras, v. 35, n. 5, p. , set./out., these instars are usually more tolerant to fast-acting insecticides (LIU et al., ; WANG et al., ). For the PET bottle method, leaves were infested with eggs and .

    NCI report (b) Bioassay of tolazamide for possible carcinogenicity (CAS no –) Google Scholar NCI Carcinogenesis Bioassay () Chlorpropamide (NCITR* NCI-CG-TR,78); tolbutamide (NCITR* NCI-CG-TR,77) Google Scholar. Committees on Toxicity, Mutagenicity, Carcinogenicity of Chemicals in Food, Consumer Products and the Environment Annual Report Committee completed its consideration of the possible effects of soya on thyroid function Carcinogenicity of Chemicals in Food, .


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Bioassay of chlorpropamide for possible carcinogenicity by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

Bioassay of chlorpropamide for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: Carcinogenesis Testing Program (U.S.) OCLC Number: Notes: This report was prepared at Tracor Jitco. Spine title: Chlorpropamide.

"CAS no. Additional Physical Format: Print version: Bioassay of chlorpropamide for possible carcinogenicity (OCoLC) Material Type: Document, Government. BIOASSAY OF. CHLORPROPAMIDE. FOR POSSIBLE CARCINOGENICITY.

Carcinogenesis Testing Program. Division of Cancer Cause and Prevention National Cancer Institute National Institutes of Health Bethesda, Maryland DREW Publication No.

(NIH ) 5. A bioassay of chlorpropamide for possible carcinogenicity was conducted by administering the test material in feed to Fischer rats and B6C3F1 mice. Groups of 35 rats and 35 mice of each sex were administered chlorpropamide as follows: rats 5 days/wk for to wk at 3, or 6, ppm, and mice 5 days wk for 34 wk at 5, or 10, ppm.

A bioassay of p-cresidine for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice. p-Cresidine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species.

The dietary concentrations used in the chronic bioassay for low and high dose rats were and A bioassay of p-phenylenediamine dihydrochloride for possible.

carcinogenicity wa conductes d using Fische 34r4 rats and B6C3F1 mice. p-Phenylenediamin dihydrochloridee was administere idn the.

feed, at either of two concentrations t,o groups of 50 male and female animal osf each species Th. higeh and low concentration s. McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W.

Responses of the LY tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded. A bioassay of technical-grade hydrazobenzene for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice. Hydrazobenzene was administered in the feed, at either of two concentrations, to groups of 50 male and 47 to 50 females animals of each species.

Long-term animal bioassays for carcinogenicity are used regularly to determine whether chemical agents are capable of inducing cancer in exposed animals. Two important aspects of current bioassays are that testing covers a substantial portion of the lifespan of the test species and that high doses.

If you are 65 or older, use chlorpropamide with care. You could have more side effects. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using chlorpropamide while you are pregnant.

How is this medicine (Chlorpropamide) best taken. Use chlorpropamide as ordered by your doctor. Chlorpropamide and other sulfonylureas encourage weight gain, so they are generally not favored for use in very obese patients. Metformin (Glucophage) is considered a better drug for these patients.

Sulfonylureas should be used with caution or generally avoided in patients with hepatic and renal impairment, patients with porphyria, patients who are breastfeeding, patients with ketoacidosis. Uses. Chlorpropamide is used with a proper diet and exercise program to control high blood sugar in people with type 2 may also be used with other diabetes lling high.

Animal Carcinogenicity Studies: 3. Alternatives to the Bioassay. carcinogenicity bioassay in the general literature and the potential for the possible incorporation of alternative tests. Therapeutics. Chlorpropamide is used in the treatment of type 2 diabetes mellitus. It has a very long duration of action (at least 24 h), and its use in the elderly may give rise to hypoglycemia; therefore, chlorpropamide is not recommended for such patients.

It may also be used in patients with diabetes insipidus due to partial deficiency of vasopressin; it requires careful use in these.

Schmeltz, B. Metzger, in Comprehensive Medicinal Chemistry II, Pharmacokinetics. Both first-generation sulfonylureas (tolbutamide, chlorpropamide, tolazamide, and acetohexamide) and second-generation sulfonylureas (glyburide, glipizide, and glimepiride) are rapidly absorbed after oral half-lives are between 4 and 10 h with the duration of glycemic.

Not drug of choice in elderly; increased risk of hypoglycemia and drug interactions because of long half-life.

Type 2 Diabetes. mg PO qDay initially; may increase or decrease PRN by mg/day at 3. bioassay conducted by administering test chemical in feed to fischer rats & b6c3f1 mice for wk.

APPARENTLY ACETOHEXAMIDE WAS NOT CARCINOGENIC FOR EITHER SPECIES. BIOASSAY OF ACETOHEXAMIDE FOR POSSIBLE CARCINOGENICITY; REPORT DHEW/PUB/NIH, NCI-CG-TR, PB ().

Chlorpropamide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 type 2 diabetes, your body does not work properly to store excess sugar and the sugar remains in your blood sugar over a long time can lead to serious health problems.

Proper diet is the first step in managing type 2 diabetes, but often medicines are needed. DIABINESE® (chlorpropamide) Tablets, USP For Oral Use. DESCRIPTION. DIABINESE® (chlorpropamide), is an oral blood-glucose-lowering drug of the sulfonylurea class. Chlorpropamide is l-[(p-Chlorophenyl)sulfonyl]propylurea, C 10 H 13 ClN 2 O 3 S, and has the structural formula.

CTAs are faster and more cost efficient than the in vivo rodent carcinogenicity assay, providing a useful approach for screening of chemicals with respect to their carcinogenic potential.

Phenacetin, paracetamol, metacetamol, oleanolic acid, tolbutamide, chlorpropamide, furafylline, dextromethorphan, 6[beta]-hydroxytestosterone, glucose 6phosphate (G6P), glucose 6-phosphate dehydrogenase (G6PDH), [beta]-nicotinamide adenine dinucleotide phosphate (NADP), and tris (hydroxymethyl) aminomethane hydrochloride (Tris-HCl) were.Compare prices, print coupons and get savings tips for Chlorpropamide (Generic Diabinese and Glucamide) and other Diabetes Type 2 drugs at CVS, Walgreens.

Diabinese (chlorpropamide) is an oral diabetes medicine used together with diet and exercise to treat type 2 (non-insulin dependent) diabetes. Other diabetes medicines are sometimes used with Diabinese if needed. Diabinese is available in generic form.

Common side effects of .